DCS EH-36SS Uživatelský manuál stáhnout pdf (Strana 113)

VII. Summary

101

scanner. The complication rate was considerably low (11%) and comparable to the

application of this model under normal conditions.

In this experiment, the development of cytotoxic brain edema was detectable within

the first minutes following middle cerebral artery-occlusion. An increase in T2-

relaxation time, that is indicative for vasogenic brain edema, could be detected as

early as 20 minutes after induction of ischemia. This result indicated a surprisingly

early breakdown of the blood-brain barrier.

In summary, application of the macrosphere-model avoids typical side-effects of the

established suture-model. This new technique allows a closer simulation of the

clinical situation of human stroke patients and thus improves the transferability of

results derived from animal studies to human stroke. The macrosphere-model

furthermore is suitable for in-bore occlusion experiments and thus facilitates

investigation during the hyperacute phase of focal cerebral ischemia.

However, the macrosphere technique does not allow reperfusion. This circumstance

represents the most important limitation of this otherwise promising new experimental

technique.

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DCS EH-36SS Uživatelský manuál Strana 113